Glipizide vs. metformin: Eseesega, mea e tutusa ai, ma o le fea e sili atu mo oe
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Glipizide ma metformin o vailaʻau e lua e faʻaaogaina e togafitia ai le Type 2 diabetes mellitus. Tagata e maua ile maʻisuka ituaiga 2 e i ai le faʻafitauli ma le homone homone, o le nafa lea ma le aveina ole suka ile toto (kulukose) ile sela ole tino mo le malosi. A le galue lelei foi le inisalini, ole teteʻe ole inisine e mafai ona atiaʻe ma taʻitaʻia ai ile faateleina ole maualuga ole kulukose, lea e mafai ona oʻo atu ai i isi faʻafitauli tau soifua maloloina. Glipizide ma metformin mafai fesoasoani fesoasoani maualuga kulukose tulaga e faʻaititia ai le aʻafiaga o faʻafitauli mai le maʻisuka.
Faʻatusatusa i sui fou, glipizide ma metformin e taugofie vailaʻau antidiabetic. E faʻaaoga uma mo le puleaina umi o le maʻisuka ituaiga 2. E ui lava e i ai a latou mea e tutusa ai i le aotelega o aʻafiaga, glipizide ma metformin e tele eseʻesega, aemaise i le auala latou te galulue ai, ono ono aʻafiaga, ma fualaʻau faʻafesoʻotaʻi.
O a eseesega autu ile va ole glipizide male metformin?
Glipizide
Glipizide o le lautele igoa mo Glucotrol. O se vaega o le vasega o vailaʻau e taʻua o le sulfonylureas, ma e aoga e faʻamalosia le faʻalilolilo o inisalini mai le papala. O le faʻateleina o le inisalini e fesoasoani e faʻaititia ai le maualuga o le kulukose i le tino.
Glipizide o loʻo avanoa e pei o le 5 mg poʻo le 10 mg oral tablet. Generic glipizide e sau foi i le lautele-faʻamalolo papa i malosiaga o le 2.5 mg, 5 mg, ma le 10 mg. Glipizide e masani ona ave tasi i aso uma ae le i fai le 'aiga o le taeao.
Metformin
Metformin o le lautele igoa mo Glucophage poʻo Riomet, ma e aofia ai i le vasega o vailaʻau taʻua o biguanides. E galue Metformin e togafitia ituaiga 2 suka e faʻaititia le suka gaosi i le ate ma faʻaititia ai le mitiia o le suka i totonu o le manava. E galue foi e ala i le faʻateleina o le inisalini lagona ma faʻateleina le aveina o kulukose i le tino o aano.
Metformin o loʻo avanoa e avea ma fofoga tautala i malosiʻaga o le 500 mg, 850 mg, ma le 1000 mg. Faʻalauteleina-faʻamalolo metformin papa o loʻo avanoa foi ma fuafuaina e ave tasi i aso uma. O le metformin vave-faʻamatuʻu e masani ona faatonuina e ave faʻalua i aso uma.
| Eseesega autu ile va ole glipizide male metformin | ||
|---|---|---|
| Glipizide | Metformin | |
| Vasega fualaʻau | Sulfonylurea | Biguanide |
| Brand / tulaga lautele | Lolomi ma faʻasalalauga lautele avanoa | Lolomi ma faʻasalalauga lautele avanoa |
| O le a le igoa igoa? | Glucotrol | Glucophage Riomet |
| O a ituaiga (s) e sau ai le vailaʻau? | Laulau laulau | Laulau laulau |
| O le a le fualaʻau masani? | 5 mg tasi aso i aso uma ae le i faia le meaai o le taeao. E mafai ona fetuʻunaʻi tui e tusa ma le tali atu ma tulaga faʻafomaʻi. Tapulaʻa maualuga fualaʻau o 40 mg i le aso. | 500 mg faʻalua faʻalua i le aso poʻo le 850 mg taʻitasi i aso uma ma taumafataga. E mafai ona fetuʻunaʻi tui e tusa ma le tali atu ma tulaga faʻafomaʻi. Tapulaʻa maualuga fualaʻau o le 2,550 mg i le aso. |
| O le a le umi o le togafitiga masani? | Taimi umi mo le puleaina o le maʻisuka | Taimi umi mo le puleaina o le maʻisuka |
| O ai e masani ona faʻaaogaina vailaʻau? | Tagata matutua 18 tausaga ma luga atu | Tagata matutua ma tamaiti taʻi 10 tausaga le matutua |
Tulaga togafitia e glipizide ma metformin
Glipizide ma metformin e faʻamaonia uma e le FDA e togafitia le Type 2 diabetes mellitus. Ole faʻatonutonu ole maualuga ole suka ile toto e mafai ona fesoasoani ile faʻaititia ole aʻafia ile maʻi suka. O nei faʻalavelave e ono aofia ai maʻi fatu, fatugaʻo faʻamaʻi, faʻamaʻi o le ate, faʻaleagaina o mata, ma faʻamaʻi vae.
Metformin e masani ona faʻaaogaina le igoa e togafitia ai isi faʻafitauli, pei ole maʻi suka, poʻo le maʻisuka i le taimi o le maʻito, ma polycystic ovary syndrome (PCOS) . Metformin o loʻo faʻaaogaina foi-igoa e togafitia ai le mauaina o le mamafa na mafua mai o se itu aʻafiaga o nisi antipsychotic vailaʻau.
Leai ni taua suʻesuʻega na faia i luga o le ese-igoa faʻaaogaina o le glipizide.
| Tulaga | Glipizide | Metformin |
| Ituaiga 2 suka suka | ioe | ioe |
| Maʻi suka | Leai | Igoa-aveese |
| Polycystic ovary syndrome | Leai | Igoa-aveese |
| Faʻateleina pauna ona o antipsychotic togafitiga | Leai | Igoa-aveese |
E sili atu le aoga o le glipizide poʻo le metformin?
Glipizide ma metformin o vailaʻau lelei o le suka e faʻaleleia ai le glycemic control i tagata e maua ile maʻisuka ituaiga 2. E mafai ona faʻaaogaina e pei o monotherapy poʻo ni fualaʻau e taʻua o le Metaglip. Glipizide ma metformin galue sili pe a faʻaogaina ma se taumafataga lelei ma faʻamalositino regimen.
Metformin tumau pea o le muamua-laina togafitiga mo Ituaiga 2 maʻisuka, e tusa ai ma taiala mai le American Diabetes Association (ADA) . A faʻatusatusa i le aoga ia i latou e maʻi suka ituaiga 2 ma faʻamaʻi toto o le alatoto, o le metformin e faʻaititia ai le aʻafia o le fatu ma faʻamaʻi e sili atu i le glipizide. E tusa ai ma le faʻalua-tauaso, faʻataʻitaʻi faʻataʻitaʻi togafitiga, metformin faʻaalia sili atu aafiaga cardioprotective nai lo glipizide ina ua mavae se vaitaimi o le lima tausaga.
Le isi faʻataʻitaʻiga faʻamasinoga maua o metformin maua lelei pulea suka suka i lo le glipizide. O i latou na faia metformin i le suʻesuʻega na sili atu le anapogi plasma kulukose tulaga nai lo le glipizide ina ua mavae 24, 36, ma 52 vaiaso. O i latou na ave metformin sa i ai foi le maualalo HbA1c tulaga nai lo i latou ave glipizide ina ua mavae 52 vaiaso. Metformin mafua ai leiloa mamafa ma glipizide mafua ai le mauaina o le mamafa i tagata na togafitia.
Faʻafesoʻotaʻi le soifua maloloina mo fautuaga faʻafomaʻi i togafitiga sili mo oe pe a fai e te maua ile maʻisuka ituaiga 2. Faʻamoemoeina i lou tulaga faʻafomai tulaga, toto suka tulaga , ma isi vailaʻau e te ono inuina, o le tasi vailaʻau ono sili atu le fiafia nai lo leisi.
Manaʻo le tau sili ile Glipizide?
Saini mo Glipizide tau faʻailo ma saili pe a suia le tau!
Maua tau mataala
Faʻatupeina ma tau faʻatusatusaga o le glipizide vs. metformin
Glipizide o se vailaʻau antidiabetic lautele e masani ona ufiufi e Medicare ma inisiua fuafuaga. Mo se sapalai masani o le glipizide, o le copay mafai ona amata atu i le $ 0 i le $ 9. O le averesi tau faʻatau o le glipizide mafai ona tusa ma le $ 30. O le SingleCare glipizide coupon e mafai ona fesoasoani e tuʻu i lalo le tau i le $ 4 i sui auai o fale talavai.
Metformin o se masani faatonuina talavai antidiabetic vailaʻau e ufiufi e le tele Medicare ma inisiua fuafuaga. O le masani Medicare copay mafai ona amata mai i le $ 0 i le $ 8, ma le tau faʻatau atu e tusa ma le $ 25 faʻamoemoe i le fale talavai e te alu i ai. Se metformin coupon mai SingleCare ono faʻaititia le tau i lalo ifo o le $ 4.
| Glipizide | Metformin | |
| Masani ufiufi e inisiua? | ioe | ioe |
| Masani ufiufi e Medicare Vaega D? | ioe | ioe |
| Tulaga masani | 5 mg faʻatasi i aso uma (aofaʻi o le 60 papa) | 500 mg faʻalua faalua i aso uma (aofaʻi o le 60 papa) |
| Masani Medicare copay | $ 0– $ 9 | $ 0– $ 8 |
| Tau nofofua | $ 4 + | $ 4 + |
Aafiaga masani masani o glipizide vs. metformin
O aʻafiaga masani a le glipizide e aofia ai le maualalo ole suka ile toto ( hypoglycemia ), papala, manava, niniva, ma niniva.
O aʻafiaga masani a metformin e aofia ai le manava tata, niniva, vaivai (astenia), hypoglycemia, ma le ulu tiga.
O aafiaga ogaoga o le glipizide e aofia ai le ogaoga o le hypoglycemia ma le hemolytic anemia. Aafiaga ogaoga o metformin aofia ai lactic acidosis ma vitamini B12 le lava. Faʻafesoʻotaʻi le soifua maloloina mo isi ono aʻafiaga o glipizide poʻo metformin.
| Glipizide | Metformin | |||
| Aafiaga itu | E talafeagai? | Faafia | E talafeagai? | Faafia |
| Hypoglycemia | ioe | * | ioe | 1% –5% |
| Paneta | ioe | * | Leai | - |
| Manava tata | ioe | * | ioe | 53% |
| Faanoi | ioe | * | ioe | 26% |
| Faanenefu | ioe | * | Leai | - |
| Vaivaiga | Leai | - | ioe | 9% |
| Tigā ulu | ioe | * | ioe | 6% |
* le lipotia
O le tele o taimi e le faʻavaeina i luga o faʻamatalaga mai le ulu-i-le-ulu faʻamasinoga. Atonu e le o se lisi atoa lea o aʻafiaga e mafai ona tupu. Faʻamolemole vaʻai i lau fomaʻi poʻo le tausi soifua maloloina ia aʻoaʻo atili.
Punavai: DailyMed ( Glipizide ), DailyMed ( Metformin )
Faʻafesoʻotaʻiga o fualaʻau o le glipizide vs. metformin
Glipizide ma metformin mafai faʻafesoʻotaʻi ma tutusa vailaʻau. O vailaʻau faʻapitoa e mafai ona faʻateleina le suka suka faʻaititia ifo aafiaga o le glipizide ma metformin, lea e mafai ona faʻateleina ai le aʻafia o le hypoglycemia. O nei vailaʻau e aofia ai isi vailaʻau antidiabetic ma ni toto e faʻateteina ai toto pei o ACE inhibitors ma angiotensin ituaiga II receptor blockers.
Nisi vailaʻau mafai faʻaititia le lelei glipizide ma metformin galue, lea e mafai ona faʻaititia ai latou toto suka faʻaititia aafiaga. O nei vailaʻau ono aofia ai poloka poloka kalisiu, diuretics, corticosteroids, beta blockers, ma fofoga puipuia. O faʻailoga o le hypoglycemia e mafai ona ufiufi a o inu beta poloka, o lea e tatau ai ona mataʻituina i tagata o loʻo inuina nei vailaʻau.
Metformin mafai foi faʻafesoʻotaʻi ma carbonic anhydrase inhibitors, pei o topiramate ma zonisamide, lea e mafai ona faʻateleina ai le aʻafiaga o lactic acidosis. O isi vailaʻau pei o le ranolazine ma le vandetanib e mafai ona fesoʻotaʻi ma metformin ma faʻalavelave ai i lona faʻateʻaina mai fatugaʻo. O nei vailaʻau mafai faʻateleina le maualuga o metformin i le toto ma faʻateleina le ono aʻafia o lactic acidosis.
| Fualaau faasaina | Vasega fualaʻau | Glipizide | Metformin |
| Topiramate Zonisamide Acetazolamide Dichlorphenamide | Mea e taofi ai le Carbonic anhydrase | Leai | ioe |
| Ranolazine | Aneti-aneti | Leai | ioe |
| Vandetanib | Tyrosine kinase taofi | Leai | ioe |
| Inisalini Sitagliptin Dulaglutide Dapagliflozin Miglitol | Antidiabetic sooupu | ioe | ioe |
| Lisinopril Enalapril C Laptopril | Aisa taofi | ioe | ioe |
| Candesartan Irbesartan Losartan | Angiotensin II receptor poloka sooupu | ioe | ioe |
| Amlodipine Nicardipine Verapamil | O poloka poloka auala | ioe | ioe |
| Hydrocortisone Prednisone Methylprednisolone | Corticosteroids | ioe | ioe |
| Hydrochlorothiazide Chlorthalidone Indapamide Furosemide Bumetanide | Diuretics | ioe | ioe |
| Atenolol Bisoprolol Metoprolol | Beta poloka | ioe | ioe |
| Faʻafefe estrogens Ethinyl estradiol Levonorgestrel Norethindrone | Estrogens ma fofoga puipuia | ioe | ioe |
Faʻafesoʻotaʻi se polofesa mo le soifua maloloina mo isi mafai fegalegaleaiga fualaʻau
Lapataiga o glipizide ma metformin
Ona o latou suka-faʻaititia aafiaga, glipizide ma metformin tauaveina se tulaga lamatia o le hypoglycemia, po o le maualalo le suka suka tulaga. O le lamatiaga o le hypoglycemia ua faʻateleina pe a fai o le glipizide poʻo le metformin e ave ma isi antidiabetic agents. Ole faʻamalositino umi ma inu 'ava malosi e ono faʻateleina ai foʻi lenei aʻafiaga. Faʻailoga o le hypoglycemia aofia ai le popolevale, afu, tataʻi vave o le fatu, ma le le mautonu.
E iai tagata e le atoatoa le kulukose 6-phosphate dehydrogenase (G6PD) e ono aʻafia ile hemolytic anemia aʻo inuina le glipizide. Peitai, o nisi tagata e aunoa ma le GP6D le lava e mafai foi ona maua i le hemolytic anemia.
O le faʻaaogaina o metformin e mafai ona taitai atu ai i le metformin-fesoʻotaʻi lactic acidosis. Lenei ituaiga o lactic acidosis e masani ona fesoʻotaʻi ma le soona inu o metformin. Peitaʻi, e iai foʻi le lamatiaga o le lactic acidosis i tagata e faʻaititia le ate poʻo le fatugao. O faʻailoga ma faʻailoga o le lactic acidosis e aofia ai le niniva, toto maualalo, ma tiga o le manava.
Faʻatalanoa ile soifua maloloina mo isi lapataiga ono mafai ma puipuiga e fesoʻotaʻi ma le glipizide poʻo le metformin.
Fesili masani e uiga ile glipizide vs. metformin
O le a le glipizide?
Glipizide o se vailaʻau lautele e ana le vasega o vailaʻau e taʻua o le sulfonylureas. O le igoa igoa o le glipizide o le Glucotrol. Glipizide galue e ala i le faʻateleina o le faʻasaʻolotoina o inisalini mai le pancreas e tuʻu i lalo le toto suka tulaga. E avanoa e avea o se vave-faʻamatuʻuina ma faʻalauteleina-tatala fofoga tautala.
O le a le metformin?
Metformin e lauiloa foi i igoa masani igoa e pei o Riomet ma Glucophage. O le vaega o vailaʻau antidiabetic valaʻauina biguanides. Metformin galue i le faʻateleina o le inisalini lagona, faʻaititia le suka i le ate, ma faʻaititia le faʻaaogaina o le suka i le toto. Metformin o loʻo avanoa e avea ma vave-faʻamatuʻuina ma faʻalauteleina-faʻatuʻu fofoga tautala.
E tutusa glipizide ma metformin?
Glipizide ma metformin e le tutusa. Glipizide o se sulfonylurea e togafitia ituaiga 2 maʻisuka i tagata matutua ma metformin o se lapoʻa e togafitia ituaiga 2 suka i tagata matutua ma tamaiti e 10 tausaga le matutua ma sili atu. Glipizide ma metformin galue i auala eseese ma eseʻese metotia.
E sili atu le glipizide poʻo le metformin?
Glipizide ma metformin uma galulue uma e tuʻu i lalo le toto kulukose tulaga ia i latou ma Type 2 maʻisuka. Faʻailoa e le American Diabetes Foundation taiala , metformin o le muamua-laina togafitiga mo Ituaiga 2 maʻisuka. Glipizide ma metformin e ono ave faʻatasi i nisi tulaga e manaʻomia ai se sili atu suka-faʻaititia aafiaga e manaʻomia. I le aotelega, o le sili ona lelei vailaʻau suka e faalagolago i lou tulaga atoa faafomai ma tali atu i le vailaau.
Mafai ona ou faʻaaogaina le glipizide poʻo le metformin a o ou maʻito?
Faʻatusatusa i metformin, glipizide ono i ai se maualuga maualuga gaioiga mafuaʻaga fetal. E tusa ai ma suesuega a manu, metformin atonu e saogalemu mo le faaaogaina i le taimi o maitaga; ae leai ni faʻaiuga suʻesuʻe i tagata ua faia. Faʻatalanoa se fomaʻi tausi soifua e filifili le filifiliga sili ona lelei mo oe a o e maʻito.
Mafai ona ou faʻaaogaina le glipizide poʻo le metformin ma le ava malosi?
E le fautuaina e faʻaaoga tele le 'ava malosi a o inuina le glipizide poʻo metformin . O le inu 'ava malosi e mafai ona mafua ai le le maalofia le maualuga o le suka ile toto ma faʻateleina ai le ono maua ile hypoglycemia poʻo le hyperglycemia. E mafai foʻi ona faʻateleina le aʻafia i le ava malosi lactic acidosis a o i luga o metformin.
O le a le taimi sili ona lelei o le aso e ave ai glipizide?
O le taimi sili ona lelei e inu ai le glipizide o loʻo leʻi faia le taumafataga ina ia faʻaititia ai le ono maua ile hypoglycemia. Afai e ave tasi i le aso, glipizide e fautuaina e ave i luma o le muamua taumafataga o le aso.
E leaga le glipizide mo fatugaʻo?
Le faʻatonutonu ituaiga 2 suka e mafai ona taʻitaʻia ai i faʻalavelave e pei o le faʻaleagaina o fatugaʻo. Peitai, glipizide e le iloa mafua ai le faʻaleagaina o fatugaʻo. O le faʻateʻaina o le glipizide e mafai ona faifai lemu i tagata e leaga fatugaʻo. O le faʻaputuputuina o le glipizide e mafai ona taʻitaʻia ai i le faʻateleina o le lamatiaga o le maualalo o le toto suka.
O le a le vailaʻau saogalemu mo le maʻisuka ituaiga 2?
Metformin e masani ona faʻatulagaina o se muamua-laina togafitiga mo Type 2 maʻisuka i le tele o tagata. E mafua ona o le metformin e fai lava si taugata, saogalemu, ma aoga. Faʻatusatusa i isi antidiabetic agents, metformin e fesoʻotaʻi ma maualalo pe tutusa HbA1c tulaga . O le faʻaaogaina o metformin e fesoʻotaʻi foʻi ma mea maualalo o le hypoglycemia nai lo isi vailaʻau pei o sulfonylureas.
